Scaled-up mRNA Vaccine Manufacturing Process
Project number:
21072
Sponsor:
UA Department of Chemical and Environmental Engineering
Academic year:
2020-2021
Project Goal: Develop and scale up an mRNA vaccine production process for the SARS-CoV-2 virus, which causes COVID-19.
mRNA technology has become a novel way to protect individuals against biological threats, including viruses. This model shows a way to produce 600 million vaccine doses annually.
Based on the mRNA vaccine production of Moderna’s COVID-19 vaccine formulation, the process design involves a combination of bioreactors and filtration systems in parallel and series to safely scale up the high throughput mRNA vaccine formulation. Safety mechanisms on two major reactions ensure quality control and consistency between batches. T7 RNA polymerase reaction and DNAse 1 reaction yield the mRNA product and are closely monitored using process control techniques. The filtration sequence maximizes purification of mRNA while minimizing product loss.
An analysis of material and energy considerations for the overall system seeks to reduce operating costs and maximize the purified mRNA product.
mRNA technology has become a novel way to protect individuals against biological threats, including viruses. This model shows a way to produce 600 million vaccine doses annually.
Based on the mRNA vaccine production of Moderna’s COVID-19 vaccine formulation, the process design involves a combination of bioreactors and filtration systems in parallel and series to safely scale up the high throughput mRNA vaccine formulation. Safety mechanisms on two major reactions ensure quality control and consistency between batches. T7 RNA polymerase reaction and DNAse 1 reaction yield the mRNA product and are closely monitored using process control techniques. The filtration sequence maximizes purification of mRNA while minimizing product loss.
An analysis of material and energy considerations for the overall system seeks to reduce operating costs and maximize the purified mRNA product.
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