Project number
27059
Organization
Kidney ADVANCE Project - NIH/ACABI
Offering
ENGR498-F2026-S2027
PROJECT INTENT. Build an undergraduate-engineering prototype that receives actual spent hemodialysate collected from dialysis treatments, selectively removes undesirable solutes, measures the residual chemistry, adds back missing constituents, mixes, re-measures, and either RELEASES or REJECTS the regenerated dialysate. Fresh commercial dialysate will serve as the reference control. The project is a bench engineering system only and is not intended for human use.
Project Background: This project builds directly on two years of UA work. Chemical Engineering students first defined the chemistry of fresh versus spent dialysate; last year's Biomedical Engineering team then used actual spent dialysate to build a working WATER ECONOMY system that removed urea/ions, filtered and disinfected the fluid, and recovered purified water. This year the goal is to regenerate the dialysate itself rather than strip it completely to water: preserve useful constituents where practical, remove harmful/excess components, determine what is missing, and reconstitute the fluid toward a defined fresh-dialysate composition.
Project Goal/Summary: Develop a closed-loop system that recaptures actual spent hemodialysate, selectively removes accumulated wastes/excess solutes, measures the remaining useful constituents, adds back what is missing, and verifies regenerated dialysate against fresh dialysate for reuse. SELECTIVELY CLEAN → MEASURE → RECONSTITUTE → VERIFY → REUSE. Long-term goal: reduce water/dialysate waste and enable smaller home and ultimately portable hemodialysis systems.
Project Background: This project builds directly on two years of UA work. Chemical Engineering students first defined the chemistry of fresh versus spent dialysate; last year's Biomedical Engineering team then used actual spent dialysate to build a working WATER ECONOMY system that removed urea/ions, filtered and disinfected the fluid, and recovered purified water. This year the goal is to regenerate the dialysate itself rather than strip it completely to water: preserve useful constituents where practical, remove harmful/excess components, determine what is missing, and reconstitute the fluid toward a defined fresh-dialysate composition.
Project Goal/Summary: Develop a closed-loop system that recaptures actual spent hemodialysate, selectively removes accumulated wastes/excess solutes, measures the remaining useful constituents, adds back what is missing, and verifies regenerated dialysate against fresh dialysate for reuse. SELECTIVELY CLEAN → MEASURE → RECONSTITUTE → VERIFY → REUSE. Long-term goal: reduce water/dialysate waste and enable smaller home and ultimately portable hemodialysis systems.